Cenforce, a medication containing sildenafil citrate, interacts dangerously with nitrates, commonly prescribed for chest pain (angina) or heart conditions. Nitrates, like nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate, work by dilating blood vessels to reduce heart workload. Sildenafil in Cenforce also dilates blood vessels by inhibiting the enzyme PDE5. When taken together, this dual vasodilating effect can lead to a dramatic and potentially life-threatening drop in blood pressure. Symptoms may include dizziness, fainting, heart attack, or stroke. Because of this severe interaction, Cenforce should never be used with nitrates. Patients must inform their doctors of all medications to prevent harmful outcomes.
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